Sparsentan requires caution due to risks of hepatotoxicity, embryo-fetal toxicity, hypotension, kidney injury, and hyperkalemia.
Patients must undergo liver function tests before starting Sparsentan and periodically during treatment. It is contraindicated in pregnancy due to embryo-fetal toxicity. Sparsentan can cause hypotension, acute kidney injury, hyperkalemia, and fluid retention. Careful monitoring and treatment adjustment are necessary for these risks

