Before taking lapatinib(Tykerb)

Critical safety information and monitoring requirements for users.

Warnings and Monitoring

Key precautions include monitoring left ventricular ejection fraction (LVEF) prior to and during treatment due to the risk of cardiac toxicity. Liver function tests must be conducted at baseline, every 4-6 weeks during therapy, and as clinically indicated. Patients should be advised to manage diarrhea promptly with antidiarrheal agents. TYKERB can cause fetal harm, requiring pregnancy verification and effective contraception use in patients of reproductive potential. Concomitant use of strong CYP3A4 inhibitors or inducers should be avoided.