Factors Affecting the Price of XALKORI

Taking 250mg crizotinib twice daily allows reaching and maintaining a steady-state plasma drug concentration within 15 days, with an average accumulation ratio of 4.8. When the dose exceeds the range of 200mg to 300mg twice daily (which is 0.8 to 1.2 times the approved recommended dose), the observed increases in the minimum steady-state concentration (Cmin) and AUC are slightly higher than the proportional increase in dose.