How well does Tryngolza(Olezarsen) work?

TRYNGOLZA is a medication used as an adjunct to diet for reducing triglyceride levels in adults with familial chylomicronemia syndrome (FCS).

Therapeutic Effect of TRYNGOLZA in Familial Chylomicronemia Syndrome (FCS)

TRYNGOLZA (olezarsen) is an APOC-III-directed antisense oligonucleotide (ASO) indicated for the management of familial chylomicronemia syndrome (FCS), a rare genetic disorder characterized by severely elevated triglyceride levels. This drug helps reduce triglycerides by targeting and inhibiting APOC-III, a protein involved in lipid metabolism. Administered subcutaneously once a month, TRYNGOLZA significantly lowers triglyceride levels, which are a key factor in the risk of pancreatitis and cardiovascular events in FCS patients. Clinical studies have shown that patients who receive TRYNGOLZA experience a reduction in triglycerides, contributing to the prevention of acute pancreatitis episodes. Further long-term effects and safety details are not specified in the description.