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Trabectedin is a chemotherapeutic agent that inhibits DNA transcription and repair, thereby leading to cancer cell death.

Therapeutic Effect and Mechanism of Action

Trabectedin for Injection exerts its therapeutic effect by intercalating into the minor groove of DNA, which disrupts DNA transcription and repair mechanisms. This leads to cell cycle arrest, apoptosis, and DNA fragmentation, particularly in neoplastic cells. It is especially effective in treating soft tissue sarcomas and certain gynecologic cancers, including ovarian cancer. Trabectedin shows promising efficacy in cases where other chemotherapy regimens have failed or in relapsed cancer. Its mechanism of action involves targeting transcriptional regulation and DNA repair pathways, which is critical in controlling the growth of cancer cells and overcoming chemoresistance.