Enstilar is an innovative topical fixed-dose combination preparation that integrates the dual effects of a vitamin D analog and a corticosteroid, specifically designed for the treatment of plaque psoriasis.
Indications for Enstilar
Primary Target Population
Approved by the U.S. FDA, Enstilar is indicated for the topical treatment of plaque psoriasis in patients aged 12 years and older.
Through its unique mechanism of action, this medication significantly improves the symptoms of psoriatic lesions.
Applicable Disease Type
This product specifically targets the lesional areas of plaque psoriasis. With a once-daily administration regimen, it can effectively control disease progression.
Specifications and Physical Characteristics of Enstilar
Pharmaceutical Composition
Each gram of the foam contains 50 micrograms of calcipotriene (equivalent to 52.2 micrograms of calcipotriene monohydrate) and 0.643 milligrams of betamethasone dipropionate (equivalent to 0.5 milligrams of betamethasone).
The specification is labeled as 0.005%/0.064%, representing the precise concentration ratio of the active ingredients.
Description of Physical Properties
The product is a white to off-white opalescent liquid, stored in a pressurized aluminum spray can.
When applied, it appears as a white to off-white foam, which gradually collapses as the propellant evaporates.
Excipients and Propellants
The base contains white petrolatum, polyoxypropylene stearyl ether, mineral oil, racemic α-tocopherol, and butylated hydroxytoluene. Dimethyl ether and butane are used as propellants.
Storage and Handling Instructions for Enstilar
Temperature Control Requirements
The storage temperature should be maintained between 20°C-25°C (68°F-77°F), with an allowable fluctuation range of 15°C-30°C (59°F-86°F).
Safety Precautions
The container is a high-pressure product; piercing or incineration is strictly prohibited.
Avoid exposure to high-temperature environments or storage temperatures exceeding 120°F (49°C).
Strict Prohibition of Freezing Storage
Management of Usage Period: After opening the can, any unused product should be discarded within 6 months.
Special Usage Guidelines
The can must be shaken thoroughly before use.
The can may be held in any orientation for spraying, except horizontally.
Summary of Precautions
This product is flammable. Keep it away from heat sources and open flames during use, and smoking is prohibited.
Store it in a safe place out of the reach of children.
Pay attention to the expiration date of the product; use of expired products is strictly prohibited.
