Who can use Duvyzat(Givinostat)?

Duvyzat (givinostat) is indicated for male patients aged 6 years and older with Duchenne muscular dystrophy (DMD), a rare genetic disorder affecting muscle function. 

Who can use Duvyzat(Givinostat)?

Eligibility requires a confirmed DMD diagnosis, and treatment should be initiated only if baseline platelet counts are ≥150 x 10⁹/L. Patients must be able to tolerate oral administration and undergo regular monitoring for adverse effects like thrombocytopenia, hypertriglyceridemia, and QTc prolongation. 

Contraindications include hypersensitivity to the drug, while caution is advised in those with cardiac disease or taking QT-prolonging medications. Pregnant women and individuals with hepatic impairment may face increased risks. Treatment must be supervised by healthcare providers experienced in managing DMD and HDAC inhibitors, with dose adjustments based on weight and tolerability.