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Before taking this medicine

Duvyzat requires careful monitoring due to potential side effects. Prior to treatment, ensure baseline platelet counts (≥150 x 10⁹/L) and triglycerides are checked . 

Precautions about Duvyzat 

Monitor blood counts every 2 weeks initially for thrombocytopenia, anemia, and neutropenia, with dose adjustments or discontinuation if severe . Regularly assess triglycerides and manage elevations with dietary changes or dose modifications . Gastrointestinal issues like diarrhea may require antiemetics; discontinue if symptoms persist . 

Avoid use in patients at risk for QTc prolongation (e.g., cardiac disease, QT-prolonging drugs) and monitor ECGs in high-risk cases . Caution with CYP3A4/OCT2 substrate medications due to potential interactions . Pregnancy is contraindicated due to fetal risk, and hepatic impairment may increase exposure . Always follow healthcare guidance for safe use.

Duvyzat(Givinostat)
Duvyzat(Givinostat)
Male patients aged 6 years and older with genetically confirmed DMD.
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Duvyzat (givinostat) is a novel histone deacetylase (HDAC) inhibitor, mainly used to treat Duchenne muscular dystrophy (DMD). It is suitable for patients aged 6 years and above, regardless of their ge...
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