Imetelstat use requires close collaboration between healthcare providers and patients. Every step—from pre-treatment preparation and infusion monitoring to daily self-management—affects treatment safety and efficacy.
I. Pre-Treatment Preparation and Evaluation
1. Disclose Complete Medical History and Current Medications
(1) Before treatment, proactively inform your physician of all past medical conditions, especially bleeding tendencies, liver/kidney function status, and infection history.
(2) Also provide a full list of all medications you are taking, including prescription drugs, over‑the‑counter products, vitamins, and herbal remedies, to avoid potential drug interactions.
2. Complete Required Baseline Tests
(1) Before starting therapy, undergo laboratory tests including complete blood count and liver/kidney function panels to establish your personal baseline health data.
(2) Women of childbearing potential must also have a negative pregnancy test before treatment initiation.
3. Understand the Pre-Medication Regimen
(1) Approximately 30 minutes before each infusion, pre‑treatment with antihistamines and corticosteroids is required to reduce the risk of infusion‑related reactions.
(2) Patients should cooperate with healthcare staff to complete this step; it must not be omitted.
II. Monitoring and Cooperation During Infusion
1. Full Cooperation with Monitoring Throughout the Infusion
(1) The drug is administered via slow intravenous infusion over about 2 hours.
(2) If you experience headache, flushing, chest tightness, joint or muscle pain, or any other discomfort during the infusion, immediately inform the nurse so that the infusion rate can be adjusted or the administration paused as needed.
(3) It is recommended to remain under observation in the hospital for at least 1 hour after the infusion ends.
2. Complete Blood Count Monitoring on Schedule
(1) In the early treatment phase, a complete blood count should be checked weekly, and then before every subsequent dose.
(2) This is critical for assessing platelet and neutrophil levels and determining whether to continue or adjust dosing. Be sure to complete these tests on time.
3. Strictly Adhere to the Dosing Interval
(1) This product is administered once every 4 weeks. Keep a record of each treatment date to avoid missing or delaying a dose.
(2) If a schedule change becomes necessary, always consult your physician; do not alter the schedule on your own.
III. Self‑Management in Daily Life
1. Watch for Signs of Bleeding and Infection
(1) In daily life, watch for new petechiae or ecchymoses on the skin, as well as unusual gum bleeding, nosebleeds, or other bleeding events.
(2) Also monitor your body temperature daily and note any sore throat, cough, or painful urination that could indicate infection.
If you notice any abnormalities, contact your medical team promptly.
2. Take Precautions to Prevent Bleeding
(1) Use a soft‑bristled toothbrush and an electric razor, and avoid injuries from sharp objects.
(2) Keep walkways clear at home to prevent tripping or bumping.
(3) If you experience black stools, blood in urine, or vomiting blood, seek immediate medical attention.
3. Comply with Contraception and Breastfeeding Requirements
(1) Women of childbearing potential must use effective contraception during treatment and for at least one week after the last dose.
(2) If you suspect pregnancy during treatment, inform your doctor immediately.
(3) Breastfeeding is not recommended during treatment and for one week after the last dose.
Note: This article provides general educational information on medication precautions. The specific treatment plan and any adjustments must follow the individualized guidance of your attending physician. This content should not be used as a basis for self‑medication.
