During the treatment period, Metyrapone should pay attention to quitting smoking and alcohol, taking medication according to the doctor's instructions, and adjusting the diet. Common adverse reactions include hypotension, nausea, vomiting, rash, anemia, diarrhea, allergic rash, etc., and patients can be treated symptomatically under the guidance of doctors to avoid aggravation of adverse reactions.

What are the precautions and adverse reactions of Metyrapone?

Adverse effects of Metyrapone include hypotension, vomiting, headache, abdominal discomfort or pain, sedation, allergic rash, leukopenia, nausea, dizziness, anemia, or thrombocytopenia.

Measures to deal with adverse reactions:

Allergic rash

Patients should pay attention to keeping the skin clean and hygienic, avoid scratching, and avoid using harsh toiletries. If the rash is accompanied by symptoms such as itching, drugs such as calamine lotion and loratadine can be used to relieve discomfort.

Nausea

During the treatment of Metyrapone, you should pay attention to a light diet, avoid eating spicy and irritating foods such as chili, barbecue, mustard, ginger, etc., and eat more fresh fruits and vegetables, such as apples, bananas, spinach, etc., which can help relieve nausea and vomiting symptoms.

Headache

Headache patients can be relieved by local massage, moxibustion or acupuncture, and should pay attention to rest, maintain adequate sleep, and use drugs such as ibuprofen to relieve pain symptoms if necessary.

In addition, patients should also pay attention to the occurrence of adverse reactions such as abdominal pain, anemia, and vomiting.

Precautions

Avoid smoking and alcohol

Smoking and alcohol should be avoided during the use of Metyrapone, so as not to interfere with the effectiveness of the drug and increase the risk of patients with adrenocortical tumors or Cushing's syndrome.

Check your blood pressure regularly

Because Metyrapone may cause an increase in blood pressure, blood pressure should be checked regularly during treatment and the treatment regimen should be adjusted appropriately as needed.

Take medication according to the doctor's instructions

It is recommended that patients strictly follow the doctor's instructions for medication treatment, remember to blindly increase the dose of drugs or stop drugs suddenly, and take drugs reasonably and standardly, so as to ensure the efficacy and safety of treatment.

Contraindications

It is forbidden for patients who are allergic to Metyrapone, adrenal insufficiency, and should be used with caution for patients with pituitary insufficiency and renal insufficiency.

Avoid driving and operating

Metyrapone may cause dizziness and sedation. Patients should not drive or operate machinery until these effects have worn off.

Acetaminophen

Metyrapone inhibits glucuronidation of acetaminophen, which may reduce the elimination of acetaminophen and lead to an increased risk of adverse effects associated with acetaminophen, so the combination of Metyrapone with acetaminophen should be avoided.

Medication for special populations

Pregnancy

The Metyrapone test was performed in pregnant women in the second and third trimesters of pregnancy and found that the fetal pituitary gland responds to enzyme blockade. Transplacental transfer of Metyrapone has been demonstrated in humans, and the drug impairs fetal and placental steroid biosynthesis. A small number of published reports have shown that babies exposed to the uterus were born with lower cortisol levels after long-term use of Metyrapone in pregnant women.

Lactating women

Metopirone and its active metabolite Metyrapone are found in human milk. There are no available data on the effects of Metyrapone on breastfed infants or on milk production. The developmental and health benefits of breastfeeding, as well as the mother's clinical need for Metyrapone, and any potential adverse effects of Metyrapone or underlying maternal disease on breastfed infants should be considered.

Pediatric use

Metyrapone is used in combination with other diagnostic tests for diagnosing adrenal insufficiency in children.

Metyrapone has a significant effect on adrenal insufficiency, and patients can take the medication correctly under the guidance of a doctor, while paying attention to strictly following the doctor's instructions.