Defibrotide is a widely recognized blood treatment drug in the international market. It is suitable for patients with hepatic veno-occlusive disease (VOD) after hematopoietic stem cell transplantation (HSCT). Defibrotide provides patients with a new treatment option.

Side effects of Defibrotide

Defibrotide (also known as Defibrotide sodium) has been widely used in clinical practice as a drug for hepatic veno-occlusive disease in adults and children in specific situations after hematopoietic stem cell transplantation. Defibrotide, like many drugs, may also cause some side effects during use. It is important for patients to understand these side effects so that they can be monitored and treated in time during medication.

Bleeding tendency

Defibrotide has anticoagulant and fibrinolytic effects, which may lead to abnormal blood coagulation function or impaired blood vessel wall integrity, thereby causing bleeding tendency. Mild symptoms may include gingival bleeding, heavy menstrual flow, etc., while severe cases may cause intracranial hemorrhage, threatening life safety.

Coagulation dysfunction

Because Defibrotide affects the blood coagulation process, patients may experience spontaneous bleeding, such as skin ecchymosis, nosebleeds, oral mucosal bleeding, etc. If these symptoms are not treated in time, they may cause organ damage or even hemorrhagic shock.

Allergic reactions

Although the probability of occurrence is low, Defibrotide may also cause allergic reactions, including rash, urticaria, angioedema, etc. Patients with a history of allergies should be particularly vigilant.

Understanding the side effects of Defibrotide is an important step for patients to use the drug safely. During use, patients should pay close attention to changes in their symptoms and report to their doctors in a timely manner so that necessary treatment measures can be taken.

Storage of Defibrotide

The correct storage method is conducive to maintaining the stability of the drug. As an injection, the storage conditions of Defibrotide need to be strictly controlled in order to achieve the best therapeutic effect when used.

Defibrotide should be stored in an environment of 20°C-25°C (68°F-77°F), and short-term storage between 15°C and 30°C (59°F to 86°F) is allowed. Ensure constant temperature to avoid excessively high or low temperatures that affect drug stability.

Use after dilution

When stored at room temperature, the diluted Defibrotide should be used within 4 hours to ensure the efficacy of the drug.

Safety considerations

Defibrotide should be kept out of the reach of children to avoid accidental ingestion or other accidents.

It is recommended that patients should strictly follow the instructions and the doctor's advice for storage and use to ensure the efficacy of the drug and reduce potential risks.

Healthy lifestyle

While properly storing and using Defibrotide, patients should also pay attention to a healthy lifestyle to improve the treatment effect and reduce the occurrence of side effects. A healthy lifestyle not only helps the recovery of the disease, but also enhances the patient's overall health.

Balanced diet

Maintaining a balanced diet and taking in enough nutrients can help enhance the body's immunity and improve the efficacy of the drug.

Moderate exercise

Moderate exercise according to physical condition, such as walking, yoga, etc., can help improve blood circulation and promote drug absorption and excretion.

Good attitude

Maintaining a positive attitude, reducing anxiety and stress, and helping to improve the body's self-repair ability and promote disease recovery.

A healthy lifestyle is an indispensable part of the use of Defibrotide, and patients should pay attention to a healthy lifestyle to achieve the best treatment effect.