Ambrisentan is primarily used for the treatment of pulmonary arterial hypertension (PAH) to improve exercise capacity and delay clinical symptoms. Like all medications, Ambrisentan may also cause certain side effects, and this article will explain the relevant details in specific terms.

What Are the Side Effects of Ambrisentan?

When using Ambrisentan, the more common adverse reactions mainly include peripheral edema, nasal congestion, sinusitis, and flushing. During the use of Ambrisentan, patients should strictly follow the doctor’s guidance and closely monitor their physical condition.

1. Peripheral Edema

Peripheral edema is a common side effect of Ambrisentan. It may occur due to the drug’s impact on vascular permeability, which leads to fluid accumulation in the interstitial spaces of tissues. This type of edema may present as swelling in the hands, feet, legs, or other parts of the body. The severity of peripheral edema varies from individual to individual. When this condition occurs, patients are advised to consult a doctor promptly to adjust the medication dosage, switch to another medication, or take other measures to alleviate the edema symptoms.

2. Nasal Congestion

Nasal congestion may be another adverse reaction caused by Ambrisentan. Although this condition is relatively less common, if it occurs, it may affect the patient’s quality of life to a certain extent. Nasal congestion may result from the irritation of the nasal mucosa by Ambrisentan. For such cases, patients are recommended to seek medical attention promptly and consult a doctor for advice. The doctor may adjust the medication dosage or provide corresponding treatment measures based on the patient’s specific situation to relieve nasal congestion symptoms.

3. Sinusitis

The occurrence of sinusitis may be attributed to Ambrisentan’s effect on the nasal mucosa, which causes mucosal congestion or swelling and triggers sinusitis symptoms. However, sinusitis can also be caused by other factors, such as infections, allergies, or other diseases. During the use of Ambrisentan, if a patient experiences sinusitis symptoms, they should consult a doctor promptly. The doctor will determine whether the sinusitis is related to the medication based on the patient’s specific condition and provide corresponding treatment recommendations.

4. Flushing

Flushing is another common side effect of Ambrisentan, characterized by redness of the skin on the face or other parts of the body. This may happen because the drug dilates blood vessels and increases blood flow. Patients are advised to communicate with their doctor to understand the cause of flushing and the corresponding management methods. Although flushing usually does not pose a serious threat to health, patients may feel uncomfortable. In such cases, the doctor may adjust the medication dosage or take other measures according to the patient’s specific situation to reduce flushing symptoms.

Friendly Reminder: The occurrence and severity of adverse reactions may vary due to individual differences. When using Ambrisentan, patients should closely monitor their physical condition and promptly report any discomfort or abnormal symptoms to their doctor.