What Are the Indications of Ambrisentan?

Ambrisentan plays an important role in the treatment of pulmonary arterial hypertension and related diseases. During use, it must be administered in accordance with medical advice to ensure the safety and effectiveness of the drug.

1. Treatment of Pulmonary Arterial Hypertension (PAH)

Pulmonary arterial hypertension may reduce patients’ quality of life and even be life-threatening in severe cases. Taking Ambrisentan can effectively lower pulmonary arterial pressure, help patients improve exercise capacity, and delay clinical deterioration.

2. Improvement of Idiopathic Pulmonary Arterial Hypertension (IPAH)

Idiopathic pulmonary arterial hypertension may be caused by factors such as poor pulmonary vascular adaptability. Ambrisentan can reduce the reactivity of pulmonary blood vessels and decrease pulmonary vascular resistance, thereby improving the symptoms of idiopathic pulmonary arterial hypertension to a certain extent.

3. Adjuvant Treatment of Pulmonary Embolism (PE)

Pulmonary embolism is a pulmonary circulation disorder caused by emboli blocking the pulmonary arteries. By lowering pulmonary arterial pressure, Ambrisentan helps improve the condition of patients with pulmonary embolism.

During the use of Ambrisentan, it must be carried out under the guidance of a doctor, and regular relevant examinations are required to determine whether the drug causes adverse effects on the body.

What Examinations Are Required While Taking Ambrisentan?

Patients need to undergo regular monitoring of liver function and blood routine. Renal function tests and electrocardiograms (ECGs) are also recommended. The specific details are as follows:

1. Liver Function Tests

Ambrisentan may have a certain impact on the liver. During the medication period, patients need to undergo regular liver function tests, including the detection of indicators such as alanine transaminase (ALT) and aspartate transaminase (AST), to assess whether liver function is normal. Liver function tests are particularly important in the early stage of medication and during long-term use.

2. Blood Routine Tests

Ambrisentan may affect the hematological system. Patients need to undergo regular blood routine tests, including red blood cell count and hemoglobin level. This helps detect potential adverse reactions such as anemia at an early stage and adjust the treatment plan in a timely manner.

3. Renal Function Tests

Although Ambrisentan mainly acts on pulmonary blood vessels, it may also have a certain impact on the kidneys. During the medication period, patients also need to pay attention to changes in renal function, such as the detection of indicators like creatinine and blood urea nitrogen (BUN).

4. Electrocardiogram (ECG) Examinations

Patients with pulmonary arterial hypertension are often accompanied by increased cardiac load. ECG examinations help evaluate changes in cardiac function and detect potential problems such as arrhythmias in a timely manner.

Friendly Reminder: The therapeutic effect of Ambrisentan varies from person to person, and individualized treatment plans must be formulated under the guidance of a doctor. When using the drug, patients need to undergo regular examinations and evaluations, and also closely monitor changes in their own symptoms.