Ambrisentan, with the English name Endobloc, is an important drug for the treatment of pulmonary arterial hypertension (PAH). Its access channels and usage methods directly affect the therapeutic effect. This article will provide patients with comprehensive medication guidance from three aspects: formal purchase channels, medication precautions, and dietary management.

Purchase Channels for Ambrisentan

Patients can obtain this medication through a variety of formal channels.

Purchase from Hospital Pharmacies

Specialized cardiovascular pharmacies in hospitals usually stock the original brand of ambrisentan, which can be purchased directly with a doctor's prescription. Patients covered by medical insurance need to complete the approval process for special medications first. Some hospitals provide medication delivery services to facilitate patients with mobility impairments.

Purchase from Designated Medical Insurance Pharmacies

Chain pharmacies designated by local medical insurance authorities can provide ambrisentan and support settlement via medical insurance cards. When purchasing, patients are required to present their medical insurance cards and prescriptions; in some cities, advance registration is necessary.

Purchase from Formal E-commerce Platforms

Certified medical e-commerce platforms offer online purchasing services for ambrisentan, which require the upload of prescription photos and medical records. Delivery usually takes 1-3 working days, and real-time reimbursement is available in regions that support online medical insurance settlement. When choosing a purchase channel, patients should verify the merchant's qualifications, check the integrity of the medication packaging, and keep the purchase receipts for future inspection.

Precautions for Ambrisentan Use

The correct use of ambrisentan is crucial for its therapeutic effect.

Principles of Dosage Adjustment

The initial dose is 5mg per day. After 4 weeks, the dose can be increased to 10mg per day based on tolerance. If adverse reactions such as peripheral edema occur, consideration should be given to reducing the dose or suspending medication. When used in combination with cyclosporine, the maximum dose should not exceed 5mg per day.

Medication for Special Populations

Women of childbearing age: Monthly pregnancy tests are required. Contraception must be used during treatment and for 1 month after discontinuing the medication.

Patients with liver impairment: Ambrisentan is contraindicated in patients with moderate to severe liver impairment; patients with mild liver dysfunction need monthly monitoring of transaminase levels.

Elderly patients: A maintenance dose of 5mg is recommended.

Monitoring of Adverse Reactions

Check hemoglobin and liver function monthly for the first 3 months of treatment, and then recheck every 3 months thereafter.

Seek medical attention immediately if severe edema, dyspnea, or jaundice occurs.

Maintain a medication diary to record the daily medication time and physical reactions, and provide this record to the doctor during follow-up visits for reference.

Dietary Precautions for Ambrisentan Use

Reasonable dietary management helps reduce drug side effects and improve therapeutic effects.

Daily Dietary Recommendations

Adopt a low-sodium diet (daily sodium intake < 2g) and consume more potassium-rich foods such as bananas and spinach.

Ensure a daily protein intake of 60-80g, prioritizing high-quality proteins such as fish and chicken breast.

Diet During Edema

When edema occurs, limit fluid intake (1000-1500ml per day) and avoid high-sodium foods such as pickled products and processed foods. Appropriate consumption of diuretic beverages like corn silk tea and red bean-coix seed water is allowed.

Foods That May Interact with the Drug

Avoid consuming grapefruit and its products, as they may affect drug metabolism.

Limit caffeinated beverages to no more than 200ml per day, and completely avoid alcoholic beverages.

Maintain regular meal times, avoid taking the medication on an empty stomach, and taking it 1 hour after meals can reduce gastrointestinal discomfort.