Anagrelide (Agrylin) is a thrombocytopenic agent primarily used to treat thrombocythemia caused by myeloproliferative neoplasms.

Indications for Anagrelide (Agrylin)

Reducing Elevated Platelet Count

This medication effectively decreases platelet production by inhibiting the maturation and differentiation of megakaryocytes.

Reducing Thrombosis Risk

Patients with thrombocythemia face a high risk of thrombosis, which may lead to serious complications such as stroke, deep vein thrombosis, or myocardial infarction.

Anagrelide significantly reduces this risk by controlling platelet count.

Improving Related Symptoms

This includes preventing and alleviating clinical symptoms such as thrombotic bleeding events.

It is particularly important for patients with gestational thrombocythemia, a condition that increases the risk of miscarriage, stillbirth, preeclampsia, and other complications.

Specifications and Properties of Anagrelide (Agrylin)

Dosage Form and Content

Anagrelide is available in capsule form, with each capsule containing 0.5 mg of anagrelide (equivalent to 0.61 mg of anagrelide hydrochloride USP).

The capsules are opaque white and imprinted with "063" in black.

Chemical Composition

Active Ingredient: 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one monohydrochloride monohydrate. Its molecular formula is C₁₀H₇Cl₂N₃O•HCl•H₂O, and its molecular weight is 310.55.

Excipient Ingredients

The capsules also contain the following inactive ingredients: Lactose Anhydrous NF, Crospovidone NF, Lactose Monohydrate NF, Magnesium Stearate NF, Microcrystalline Cellulose NF, and Povidone NF.

The capsule shell is composed of gelatin, titanium dioxide, and black iron oxide.

Physicochemical Properties

Anagrelide hydrochloride is an off-white powder. It is very slightly soluble in water and slightly soluble in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF).

Storage Methods for Anagrelide (Agrylin)

Temperature Control

Store at room temperature below 25°C, avoiding high temperatures and freezing.

Extreme temperatures may affect capsule stability and drug efficacy.

Humidity Management

Keep in a dry environment to prevent capsules from absorbing moisture and deteriorating.

Do not remove the desiccant in the original packaging in advance.

Light Protection

Due to the risk of photosensitivity, avoid direct sunlight and store in the original packaging to protect from light.

Safe Storage

Must be kept out of the reach of children to prevent accidental ingestion.

Expired medications should be disposed of through professional channels and not discarded randomly.

Transportation Requirements

During transportation, avoid severe vibration and extreme temperature changes, and ensure the medication packaging remains intact.