How well does Metopirone(Metyrapone) work?

Metopirone (metyrapone) is used for the diagnostic evaluation of adrenal insufficiency, aiding in the assessment of the adrenal gland’s ability to produce cortisol under specific conditions.

Therapeutic Effect of Metopirone in Clinical Use

Body content: Metopirone, an oral diagnostic agent, is primarily used in the context of testing for adrenal insufficiency. The drug works by inhibiting 11β-hydroxylase, an enzyme involved in cortisol synthesis, which results in a temporary reduction in cortisol production. This mechanism allows for the evaluation of adrenal function, specifically the adrenal glands' ability to respond to exogenous ACTH (adrenocorticotropic hormone). 

The therapeutic effect of Metopirone is confined to its diagnostic role in determining the presence of adrenal insufficiency, and it is not used for treatment purposes. It is typically used in combination with other tests as part of a comprehensive diagnostic approach for both adult and pediatric patients. Not specified in the description: No further therapeutic effects for other conditions are mentioned in the document.