Who can use Metopirone(Metyrapone)?

Metirapone is a specific adrenal steroid biosynthesis inhibitor. Its target focuses on 11-β hydroxylase in adrenal cortical cells. 

Who can use Metopirone(Metyrapone)?

By blocking the final synthesis steps of cortisol and corticosterone, it relieves the negative feedback regulation of endogenous cortisol on pituitary adrenocorticotropic hormone (ACTH). This mechanism can significantly increase the secretion level of ACTH, promoting the accumulation of the precursor substance 11-deoxycortisol in the blood.

With its unique pharmacological effects, Metirapone has opened up a new path in the field of endocrine therapy. As an adrenal cortical inhibitor, it is mainly used to regulate the body's cortisol levels, especially playing a key role in the treatment of cortisol excess disorders such as Cushing's syndrome.