Tysabri(Natalizumab) Side Effects

Most common adverse reactions (incidence ≥ 10%):

In patients with MS: Headache, fatigue, arthralgia, urinary tract infection, lower respiratory tract infection, gastroenteritis, vaginitis, depression, limb pain, abdominal discomfort, non-specific diarrhea, rash.

In patients with CD: Headache, upper respiratory tract infection, nausea, fatigue.

Serious adverse reactions: PML (Progressive Multifocal Leukoencephalopathy), herpes infections (encephalitis, meningitis, acute retinal necrosis), hepatotoxicity, hypersensitivity reactions (including anaphylactic shock), immunosuppression-related infections, hematological abnormalities (e.g., thrombocytopenia).