Cabergoline is a dopamine receptor agonist belonging to the class of ergot derivatives. First approved for medical use in the United States in 1996, it is primarily indicated for the treatment of specific endocrine disorders.

What are the indications for Cabergoline?

Primary Indications

Cabergoline is indicated for the treatment of hyperprolactinemia.

This disorder is characterized by abnormally elevated serum prolactin levels, which may be idiopathic (of unknown cause) or secondary to a pituitary adenoma.

By agonizing dopamine D2 receptors, the drug directly inhibits prolactin secretion from pituitary lactotrophs, thereby effectively reducing prolactin levels in patients.

Usage Restrictions

Cabergoline is strictly contraindicated for the suppression or cessation of physiological postpartum lactation.

Severe cases of hypertension, stroke, myocardial infarction, seizures and even death have been reported with the off-label use of bromocriptine, another dopamine agonist, for this purpose.

Cabergoline should be avoided for the suppression of postpartum lactation for any reason, and alternative, safer medical regimens should be selected instead.

Dosage Form, Strength and Description of Cabergoline

Dosage Form and Strength

Cabergoline is currently available in a single strength: each tablet contains 0.5 mg of cabergoline.

The medicinal product is supplied in bottles, with a common packaging of 8 tablets per bottle.

Description

Cabergoline tablets are white and capsule-shaped.

One side of the tablet is marked with a functional score line (for accurate splitting into half-tablets), with the letters "P" and "U" printed on either side of the score line, and the number "700" engraved on the other side.

The active ingredient in the tablets is cabergoline, and the inactive excipients include leucine and lactose.

Storage and Disposal of Cabergoline

Storage Conditions

Cabergoline tablets should be stored at a controlled room temperature of 20°C to 25°C (68°F to 77°F).

The tablets must be kept in the original container to protect the drug efficacy from environmental factors such as light and moisture.

Safety Precautions

Keep this and all other medicinal products out of the reach and sight of children to prevent accidental ingestion.

If the medicinal product has expired or is no longer needed, consult a pharmacist or dispose of it safely in accordance with local regulations; do not discard it at will.