Danazol has been widely used in the clinical treatment of a variety of diseases, in order to help patients better understand and use this drug, this instruction will introduce the main information of Danazol in a concise and clear way, including the basic characteristics of the drug, indications, dosage, adverse reactions, precautions and drug interactions.

Danazol(Danocrine) instructions: indications

Endometriosis

Danazol is indicated for endometriosis on hormonal therapy.

Fibrocystic breast disease

Most cases of symptomatic fibrocystic breast disease can be treated with simple measures.

In a small number of patients, symptoms of pain and tenderness may be severe enough to be treated by suppressing ovarian function. Danazol is usually effective in reducing nodules, pain, and tenderness. This treatment is not harmless, as it involves a fairly high alteration of hormonal levels, and there is a recurrence of symptoms after stopping treatment.

Hereditary angioedema

Danazol is used to prevent episodes of angioedema in all types (skin, abdomen, larynx) in both men and women.

Recommended dose

Endometriosis

For patients with moderate to severe disease or endometriosis infertility, a starting dose of 800mg is recommended in two divided doses. For patients with mild disease, an initial daily dose of 200mg to 400mg is recommended to be given in two divided doses, which can be adjusted by doctors according to the patient's response.

Fibrocystic breast disease

The total daily dose of Danazol for the treatment of fibrocystic breast disease ranges from 100mg to 400mg, administered in two divided doses depending on the patient's response.

Hereditary angioedema

The dosing requirements for the ongoing treatment of hereditary angioedema with Danazol should be individualized based on the patient's clinical response. Patients are advised to start taking 200 mg 2-3 times a day. After a good initial response to the prevention of edema episodes, the appropriate sustained dose should be determined by reducing the dose by 50% or less every 1 to 3 months or more if the pre-treatment episode frequency requires it. In case of seizures, the daily dose can be increased by up to 200 mg. During the dose adjustment phase, clinicians should closely monitor the patient's response, particularly those with a history of airway involvement.

Applicable population

For adult patients, please take medication under the guidance of a doctor.

Contraindications

Danazol should not be used in patients with:

1. Undiagnosed abnormal genital bleeding.

2. Significant impairment of liver function, kidney function or cardiac function.

3. Pregnancy and breastfeeding.

4. Patients with porphyria

Danazol induces alanine synthase activity, thereby promoting porphyrin metabolism.

6. Androgen-dependent tumors

7. Active thrombotic or thromboembolic disease and its history.

8. Allergy to Danazol.

Side effects

Common adverse reactions are: androgen-like, menstrual disturbances, flushing, sweating, vaginal dryness, irritation, and breast reduction; abnormal semen volume, viscosity, sperm count, and sperm motility; Adverse reactions such as liver dysfunction, abnormal laboratory tests, allergic reactions, central nervous system effects, gastrointestinal reactions, musculoskeletal reactions, genitourinary reactions, hematological reactions, skin reactions, increased insulin requirements in diabetic patients, changes in libido, myocardial infarction, palpitations, tachycardia, increased blood pressure, interstitial pneumonia, etc.; Adverse reactions such as cataract, bleeding gums, fever, pelvic pain, and nipple discharge are rare; Rare malignant liver tumors have been reported after long-term use.

Precautions

Danazol is contraindicated during pregnancy; Danazol may increase the risk of blood clots; Treatment with Danazol may also be associated with a risk of liver disease; Danazol has been associated with several cases of benign intracranial hypertension (also known as pseudotumor cerebri).

Drug interactions

It is not recommended to combine Danazol with warfarin, carbamazepine, antidiabetic drugs, cyclosporine and tacrolimus, synthetic vitamin D analogues, statins.

Storage conditions

Store at room temperature between 15 °C and 30 °C.