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Danazol(Danocrine)
Reminder: The outer packaging is for reference only, please purchase and use under the guidance of a pharmacist. For read by medical and pharmaceutical professionals only.
Danazol(Danocrine) Instructions:Uses,Dosage, Side Effects
Danazol, sold as Danocrine, is a synthetic steroid derived from ethisterone. Available in 50 mg, 100 mg, and 200 mg capsules, it suppresses the pituitary-ovarian axis, has weak androgenic activity, and can decrease autoantibodies, used for endometriosis, fibrocystic breast disease, and hereditary angioedema.
It is lipophilic, metabolized with metabolites excreted renally and fecally, and has a half-life varying from 9.7 hours in healthy males to 23.7 hours in endometriosis patients. Side effects include androgenic effects and potential hepatic issues, with contraindications like pregnancy and liver dysfunction.
1. Endometriosis: Danazol is suitable for the hormone therapy of endometriosis.
2. Fibrocystic breast disease: Most cases of symptomatic fibrocystic breast disease can be treated with simple measures. In a few patients, the symptoms of pain and tenderness may be severe enough to require treatment by inhibiting ovarian function. Danazol is usually effective in reducing nodules, pain, and tenderness. This treatment is not harmless, as it involves considerable changes in hormone levels, and symptom recurrence occurs after stopping the treatment.
3. Hereditary angioedema: Danazol is used to prevent all types (skin, abdominal, laryngeal) of angioedema attacks in both men and women.
For endometriosis, start with 800 mg/day divided, adjust to maintain amenorrhea; mild cases 200–400 mg/day. For fibrocystic breast disease, 100–400 mg/day divided. For hereditary angioedema, start 200 mg 2–3 times daily, adjust based on response.
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