In the process of using Danazol, patients must strictly follow the instructions or doctor's instructions for medication, pay attention to various matters when using the drug, and ensure the smooth progress of treatment.

What are the precautions for Danazole?

Danazol is a prescription drug, and patients should be aware of the following medications when taking Danazol for treatment.

Danazol is contraindicated during pregnancy

Patients are advised to have sensitivity tests to identify early pregnancy (e.g., β subunit trials) immediately prior to initiation of treatment, and patients should use non-hormonal methods of contraception during treatment. 

If the patient becomes pregnant while taking Danazol, the drug should be stopped, and doctors need to inform the patient of the potential risks of Danazol to the fetus. Exposure to Danazol in utero may have male hormonal effects on the female fetus, and there have been reports of clitoral hypertrophy, labial fusion, urogenital sinus defects, vaginal atresia, and genital blurring in female fetuses.

Risk of blood clots

Thromboembolism, thrombosis, and thrombotic venous thrombotic events, including sagittal sinus thrombosis and life-threatening or fatal stroke, have been reported in patients taking Danazol.

Risk of liver disease

Long-term experience with Danazol is limited, and liver abscess and benign hepatic adenoma can be observed with long-term use. Liver disease and hepatic adenoma may be asymptomatic until complicated by acute, potentially life-threatening intra-abdominal hemorrhage, and clinicians should be alert to the possibility of patients being treated with Danazol. 

Clinicians should try to determine the lowest dose that provides adequate protection, and if the patient starts medication when hereditary angioedema worsens due to trauma, stress, or other reasons, they should consider periodically trying to reduce or stop treatment.

Intracranial hypertension

Danazol has been associated with several cases of benign intracranial hypertension (also known as pseudotumor cerebri). Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea and vomiting, and visual disturbances. Patients presenting with these symptoms should be screened for papilledema, and if papilledema is present, patients should be advised to immediately discontinue Danazol and be referred to a neurologist for further diagnosis and care.

During the use of Danazol, patients should also pay attention to possible adverse reactions, such as menstrual disorders, androgen-like, etc., and hope that patients can carefully understand the adverse reactions and precautions of Danazol during the treatment of Danazol, and pay close attention to their own drug reactions to maintain their own health and safety.