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What are the adverse effects of Danocrine?
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Article source: Seagull Pharmacy
Jul 01, 2025

As an effective therapeutic drug, Danocrose is widely used in clinical practice. When patients are treated with Danazol, there may be some side effects of the drug, which may have a certain impact on the patient's physical health and treatment effect, which are described in detail below.

What are the adverse effects of Danocrine?

Danazol is commonly used in the treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema in clinical practice.

Androgen-like

Androgen-like adverse effects include weight gain, acne and sebum exudation, and, rarely, clitoral hypertrophy.

Menstrual disorders

Menstrual disorders include spotting, changes in the menstrual cycle, and amenorrhea.

Decreased estrogen levels

Flushing, sweating, vaginal dryness, irritation, and breast reduction.

Decreased spermatogenesis

Abnormal semen volume, viscosity, sperm count, and sperm motility.

Liver dysfunction

These include elevated serum enzymes and/or jaundice.

Abnormal laboratory tests

Including glucose tolerance, glucagon, thyroid-binding globulin, etc.

Allergic reactions

Hives, itching, nasal congestion.

Central nervous system effects

headaches, nervousness, and emotional instability, among others.

Gastrointestinal reactions

Gastroenteritis, nausea, vomiting, constipation, and, rarely, pancreatitis and splenic fibrosis.

Musculoskeletal reactions

Muscle spasms or spasms, or pain, arthralgia, joint atresia, etc., are rarely the result of carpal tunnel syndrome secondary to fluid retention.

Genitourinary reactions

Hematuria, prolonged amenorrhea after treatment.

Hematological reactions

Increased red blood cell and platelet count, eosinophilia, leukopenia, thrombocytopenia, etc.

Skin reactions

Rash and, rarely, sun sensitivity, Stevens-Johnson syndrome, and erythema multiforme.

Other adverse reactions

increased insulin requirement, changes in libido, myocardial infarction, palpitations, tachycardia, increased blood pressure, interstitial pneumonia in diabetic patients; less commonly, cataracts, bleeding gums, fever, pelvic pain, nipple discharge; Rare malignant liver tumors have been reported after long-term use.

Patients should strictly follow the doctor's medication guidance when using Danazol, pay attention to their own drug reactions, and inform the doctor in time once they find any abnormal symptoms, and take certain measures according to the doctor's guidance, and do not adjust the dosage by themselves.

Note: For internal discussion among medical personnel only. For specific medication, please consult the attending physician. Drug information may change over time. For the latest information, we recommend adding a medical consultant or consulting for free online.
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