Phenobarbital is a drug used to treat certain types of epilepsy. Its detailed Chinese instructions are important for patients and medical professionals. This article will introduce the instructions for use, contraindications and indications of Cenobamat in detail to help readers better understand and apply the drug.

Instructions for use of Cenobamat

Understanding the detailed instructions for use of Cenobamat is the key to ensuring the therapeutic effect and reducing side effects. This section will introduce the basic information, usage and dosage of the drug and precautions.

Basic information

Cenobamat was developed by ANGELINI, Italy, and approved by the US FDA in 2019. The main ingredient is Cenobamat, and the dosage form is tablets with a variety of specifications to choose from.

Usage and Dosage

Cenobamat is taken orally once a day, with or without food. The recommended daily dose for adults ranges from 12.5mg to 200mg. The dose for patients with liver damage needs to be adjusted according to specific circumstances.

Storage method

Cenobamat should be kept in a dry place, sealed and protected from light, and the temperature should be controlled between 20°C and 25°C. Avoid exposure to extreme heat or cold and check the integrity of the package regularly.

Following the correct instructions for use will help maximize the therapeutic effect of Cenobamat and reduce the risk of adverse reactions.

Contraindications of Cenobamat

While Cenobamat is an effective treatment option for many patients, it is not suitable for everyone. Understanding its contraindications is important to prevent potential serious health risks.

Allergic reactions

Patients who are allergic to the components of Cenobamat should not use this drug. If symptoms such as fever and rash occur, the drug should be stopped immediately and medical help should be sought.

QT interval shortening related issues

Cenobamat should not be used in patients with familial short QT syndrome because such patients may have an increased risk of sudden death and ventricular arrhythmias. At the same time, caution should be exercised when using Cenobamat and other drugs that may shorten the QT interval.

Central nervous system depressants and alcohol

The concomitant use of Cenobamat with other central nervous system depressants (including alcohol) may increase the risk of drowsiness and sedation. Therefore, patients should try to avoid drinking alcoholic beverages.

Identifying contraindications for Cenobamat not only helps avoid unnecessary health risks, but also guides physicians to develop more personalized treatment plans.

Indications for Cenobamat

Cenobamat is indicated for a variety of specific types of epilepsy and other neurological diseases. Clarifying its indications can help select the most appropriate treatment options.

GABAA receptor modulation

Cenobamat primarily acts on GABAA receptors to reduce the frequency of epileptic seizures by enhancing inhibitory neurotransmission. This mechanism makes it excellent in controlling partial-onset epilepsy.

Locally advanced or metastatic non-small cell lung cancer

Cenobamat is indicated for adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have a KRAS G12C mutation as determined by an FDA-approved test and have received at least one prior systemic therapy.

Other uses

Although Cenobamat is primarily used to treat epilepsy, its potential use in other neurological diseases is also being studied. This provides hope for possible expanded uses in the future.

Clarifying the indications for Cenobamat not only helps guide clinical applications, but also provides direction for further research. By gaining a deeper understanding of this information, doctors can more accurately assess each patient's specific situation and make the most appropriate treatment decisions.