Symproic(Naldemedine) is a drug used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. This article will focus on side effects and precautions, indications, and contraindications to help readers fully understand the key points of using Naldemedine.

Side effects and precautions of Naldemedine

Although Naldemedine is effective in treating constipation caused by opioids, it may also be accompanied by some adverse reactions and risks. Understanding these side effects and precautions will help patients use the drug safely.

Common side effects

Common side effects of Naldemedine include abdominal pain, diarrhea, nausea, and gastroenteritis, with an incidence of ≥2%. These symptoms are usually mild, but if they persist or worsen, you need to seek medical attention in time. Some patients may be more sensitive to the drug due to individual differences, and the medication regimen needs to be adjusted according to the actual situation.

Special precautions

When using Naldemedine, be alert to the risk of gastrointestinal perforation, especially in patients with gastrointestinal diseases. If severe or persistent abdominal pain occurs, stop the drug immediately and seek medical attention. In addition, patients with impaired blood-brain barriers may face the risk of opioid withdrawal and need to closely monitor related symptoms.

Although the side effects of Naldemedine are mostly mild to moderate, they cannot be ignored. Patients should take the medicine under the guidance of a doctor, monitor their physical condition regularly, and respond to possible adverse reactions in a timely manner.

Indications of Naldemedine

Naldemedine is mainly used to treat constipation in specific populations. Its indications are clear and targeted. Understanding its indications helps to determine whether the drug is suitable for use.

Applicable population

Naldemedine is suitable for adult patients with chronic non-cancer pain who suffer from opioid-induced constipation, including patients with chronic pain related to previous cancer or its treatment. Patients need to use opioids for a long time and do not need to increase the dose frequently.

Medication restrictions

Patients who have taken opioids for less than 4 weeks have a poor response to Naldemedine and are not recommended. If opioid treatment is stopped, Naldemedine should also be discontinued simultaneously to avoid unnecessary risks.

The indications of Naldemedine are clear and designed for specific populations. Patients must strictly comply with the medication conditions to achieve the best therapeutic effect.

Contraindications of Naldemedine

Naldemedine is not suitable for all people and must be prohibited or used with caution in some cases. Understanding its contraindications can avoid potential health risks.

Prohibited population

Patients with severe liver damage should avoid using Naldemedine. In addition, the safety and effectiveness of pediatric patients have not been confirmed and are not recommended. Pregnant and lactating women should also be cautious and only consider using the drug when the benefits outweigh the risks.

Use with caution

Patients with mild or moderate liver damage do not need to adjust the dose, but still need to be closely monitored. The elderly may be more sensitive to drugs and need to evaluate the medication regimen individually.

The contraindications of Naldemedine involve many types of people, and a comprehensive assessment of the patient's condition is required before using the drug. Reasonable avoidance of contraindications is the key to ensuring drug safety.