Naldemedine is a drug used to treat opioid-induced constipation (OIC) in adult patients with chronic non-pathological pain. It helps relieve constipation symptoms by selectively antagonizing μ opioid receptors without affecting the analgesic effect of opioids. The price of Naldemedine varies depending on the specifications and manufacturers. Patients should carefully identify the authenticity and production date of the drug when choosing.

How much does Naldemedine cost?

The price of Naldemedine varies depending on the specifications and manufacturers. Naldemedine produced by Shionogi Pharmaceutical in Japan has a specification of 0.2mg*50 tablets; the specification is 0.2mg*14 tablets. Patients can purchase the drug through regular medical service institutions or cross-border e-commerce platforms.

Price and specifications of Naldemedine

The price of Naldemedine is closely related to its specifications. 0.2mg*50 tablets is produced by Shionogi Pharmaceuticals of Japan. Patients can choose the appropriate specifications according to their needs.

Precautions for purchasing Naldemedine

When purchasing Naldemedine, patients should pay attention to the authenticity and production date of the drug. Avoid buying fake or inferior drugs that affect the treatment effect. After purchase, patients should properly store the drugs to avoid moisture or light.

The price of Naldemedine varies depending on the specifications and manufacturers. Patients should carefully identify the authenticity and production date of the drugs when choosing. We will introduce the targets of Naldemedine.

Targets of Naldemedine

Naldemedine helps relieve opioid-induced constipation (OIC) by selectively antagonizing the μ opioid receptor without affecting the analgesic effect of opioids. This mechanism of action makes it show significant efficacy in the treatment of OIC.

Mechanism of action of Naldemedine

Naldemedine blocks the action of opioids in the intestine by selectively antagonizing μ opioid receptors, thereby relieving constipation symptoms. This selective antagonism does not affect the analgesic effect of opioids in the treatment of OIC, helping patients improve their quality of life.

Indications of Naldemedine

Naldemedine is suitable for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-lesional pain, including patients with chronic pain related to previous lesions or their treatment. It helps patients maintain normal intestinal function by relieving constipation symptoms.

The target of action of Naldemedine determines its unique efficacy in the treatment of OIC. Next, we will introduce the use of Naldemedine in special populations.

Use of Naldemedine in special populations

The use of Naldemedine in different populations needs to be adjusted according to the specific conditions of the patient. Especially for pregnant women, lactating women and patients with liver damage, special attention should be paid when using Naldemedine.

Lactating women

When lactating women use Naldemedine, the drug may be passed to the baby through breast milk, causing opioid withdrawal symptoms in the baby. It is recommended that lactating women stop breastfeeding while using Naldemedine, or resume breastfeeding 3 days after stopping the drug.

Pregnant women

When pregnant women use Naldemedine, the fetus may experience opioid withdrawal symptoms. Naldemedine should be used during pregnancy only when the potential benefits outweigh the potential risks. Pregnant women should consult a doctor before use to evaluate the risks and benefits of the drug.

Naldemedine is a prescription drug. Patients should strictly follow the doctor's instructions when using it, and have regular checkups to prevent possible serious adverse reactions.