Tirzepatide is a dual agonist of glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 (GLP-1) receptor, which has a good therapeutic effect on adult type 2 diabetes. This article mainly explains the relevant content of Tirzepatide to help everyone better understand Tirzepatide.

People who are contraindicated for the use of Tirzepatide

Although Tirzepatide has a relatively good therapeutic effect, it is not suitable for everyone. The following people are contraindicated for Tirzepatide:

1. Patients with personal or family history of medullary thyroid cancer and patients with multiple endocrine neoplasia syndrome type 2 (MEN2)

This is mainly because Tirzepatide has the risk of causing medullary thyroid tumors. Therefore, patients with personal or family history of medullary thyroid tumors or patients with multiple endocrine neoplasia syndrome type 2 (MEN 2) are prohibited from using this drug to avoid increasing the risk of medullary thyroid tumors.

2. Patients who are known to be allergic to this product and its excipients

Patients who are allergic to Tirzepatide and its excipients may experience allergic reactions when taking Tirzepatide. This is mainly because when the human body comes into contact with allergens such as Tirzepatide, the immune system mistakenly identifies it as an invading harmful substance, which in turn produces an excessive immune response. In mild cases, discomfort symptoms such as skin itching and rash may occur. In severe cases, symptoms such as laryngeal edema, dizziness, and difficulty breathing may occur, and even anaphylactic shock may occur, endangering one's own life safety.

If patients with the above conditions misuse Tirzepatide, they should go to the hospital in time for treatment according to their own symptoms. If allergic reactions occur, they can take anti-allergic drugs such as loratadine as prescribed by the doctor.

Other precautions for the use of Tirzepatide

All drugs have certain drug toxicity. Therefore, during the use of Tirzepatide, pay attention to the following situations to reduce or avoid adverse damage caused by drugs to the body.

1. Gastrointestinal discomfort symptoms

Common adverse reactions of Tirzepatide include indigestion, abdominal pain, nausea, vomiting, constipation, diarrhea, loss of appetite, etc., which are mainly gastrointestinal discomfort symptoms. Therefore, it is not recommended to use Tirzepatide in patients with severe gastrointestinal diseases to avoid aggravating gastrointestinal diseases.

2. Combination with insulin secretagogues or insulin

Clinical studies have found that patients who use Tirzepatide in combination with insulin secretagogues (such as sulfonylureas) or insulin have an increased risk of hypoglycemia. Therefore, it is not recommended to blindly combine drugs. Doctors generally inform patients of the risks of using these combined drugs. If there is a requirement for combined drugs, the patient's clinical signs will generally be monitored.

In addition to the above precautions, patients should also pay attention to the occurrence of adverse events such as pancreatitis, acute kidney injury, complications of diabetic retinopathy in patients with a history of diabetic retinopathy, and acute gallbladder disease during medication.

Everyone's physical condition and lifestyle are not exactly the same, so the treatment plan for the same disease will also be different. The doctor will ask the patient's medical history, family medical history, allergy history and other information in detail, and combine the physical examination and laboratory test results to develop a personalized treatment plan. Therefore, you should ask your doctor for advice while using Tirzepatide.