How should I use Dayvigo(lemborexant)?

Lemborexant is a non-benzodiazepine sleep medication. Appropriate dosage and administration timing ensure it optimally promotes sleep, helping patients improve difficulties with sleep onset and maintenance.

How should I use Dayvigo(lemborexant)?

1. Routine Administration Information

The standard starting dose of lemborexant is 5 mg, taken once nightly at bedtime, with at least 7 hours remaining before the planned wake-up time. This ensures the drug acts effectively at night and avoids residual effects the next morning. Based on clinical response and tolerance, the dose may be gradually increased to the maximum recommended 10 mg. If taken with or shortly after a meal, delayed sleep onset may occur.

2. Concomitant Use with CYP3A Inhibitors or Inducers

Avoid concomitant use with strong or moderate CYP3A inhibitors.

When co-administered with weak CYP3A inhibitors, the maximum recommended dose is limited to 5 mg once nightly.

Avoid use with strong or moderate CYP3A inducers, as inducers accelerate drug metabolism, reduce plasma concentrations, and may impair efficacy.

3. Dosage Recommendations for Patients with Hepatic Impairment

For patients with moderate hepatic impairment, the maximum recommended dose is 5 mg once nightly.

Use in patients with severe hepatic impairment is not recommended.

Lemborexant administration requires individualized adjustment based on the patient’s condition, particularly when combined with other medications or in the presence of hepatic impairment. Patients should closely monitor their responses and seek medical attention promptly if discomfort occurs.