How should I use Bylvay(Odevixibat)?

Dosage is weight-based and administered once daily with a morning meal, with specific instructions for different formulations.

Administration Guidelines

The recommended dosage for PFIC starts at 40 mcg/kg once daily, which can be increased to 120 mcg/kg if no pruritus improvement is observed after 3 months. For ALGS, the dosage is 120 mcg/kg once daily. Capsules should be swallowed whole, while oral pellets must be opened and mixed with soft food or liquid. Administration should occur with the first morning meal, and dosing must be separated by at least 4 hours from bile acid binding resins to avoid interaction.