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Fidaxomicin(DIFICID)
Reminder: The outer packaging is for reference only, please purchase and use under the guidance of a pharmacist. For read by medical and pharmaceutical professionals only.
DIFICID(Fidaxomicin) Instructions:Uses,Dosage, Side Effects
DIFICID® (fidaxomicin) is a macrolide antibacterial indicated for treating Clostridioides difficile-associated diarrhea (CDAD) in adults and pediatric patients ≥6 months old. It acts locally in the gastrointestinal tract by inhibiting bacterial RNA synthesis via binding to RNA polymerases, exhibiting bactericidal activity against C. difficile.
Administered orally as tablets (200 mg) or suspension (40 mg/mL), the standard regimen is twice daily for 10 days. Clinical trials demonstrate non-inferiority to vancomycin for initial cure, with superior sustained response rates 25 days post-treatment. Common adverse reactions include nausea, vomiting, abdominal pain, and anemia in adults. Minimal systemic absorption limits its use to CDAD only.
1. Indicated for the treatment of Clostridium difficile-associated diarrhea (CDAD) in adult and pediatric patients aged 6 months and older.
2. To reduce the development of drug-resistant bacteria and maintain the effectiveness of fidaxomicin and other antibacterial agents, fidaxomicin should only be used to treat infections that are proven or strongly suspected to be caused by Clostridium difficile.
The recommended dose of fidaxomicin for adult patients is one 200mg fidaxomicin tablet, taken twice daily for 10 consecutive days.
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