Before taking Symproic(Naldemedine)

Naldemedine should be used cautiously in patients with gastrointestinal obstructions or those at risk for opioid withdrawal, and it requires close monitoring for severe abdominal pain and other adverse effects.

Warnings and Precautions  

Naldemedine should be avoided in patients with known or suspected gastrointestinal obstruction, as it may exacerbate or lead to gastrointestinal perforation. Patients with conditions affecting the integrity of the gastrointestinal tract, such as peptic ulcers or diverticular disease, require close monitoring for severe or worsening abdominal pain. 

Additionally, caution is advised in patients who may experience opioid withdrawal symptoms due to disruptions in the blood-brain barrier. Regular monitoring for symptoms such as sweating, chills, and abdominal discomfort is essential to ensure the safety of the patient during treatment with naldemedine.