Glutathione Tablets are commonly used clinical drugs for detoxification and liver protection. Clarifying their indication scope, mastering contraindicated groups, and understanding medication principles for special populations are the foundation to ensure safe and effective drug use.

I. Indications of Glutathione Tablets

1. Drug Poisoning

(1) Glutathione has detoxifying effects on various drug poisonings.

(2) It participates in the detoxification process by providing sulfhydryl groups, promotes the metabolism and excretion of toxic substances, and reduces damage to organs such as the liver.

(3) It is applicable to drug-related poisoning such as overdose of antipyretic and analgesic drugs and liver injury caused by certain antibiotics.

2. Metal Poisoning

(1) Glutathione has a definite curative effect on metal poisoning such as lead poisoning and methylmercury poisoning.

(2) Heavy metal ions can bind to the sulfhydryl groups of glutathione to form non-toxic complexes, which are excreted through urine, thereby reducing the body's metal load and alleviating toxic reactions.

3. Acetonemic Vomiting

(1) Acetonemic vomiting, also known as autointoxication or cyclic vomiting syndrome, is more common in children.

(2) The disease is characterized by recurrent severe vomiting and ketonemia. Glutathione can improve metabolic disorders in the body, reduce ketone body accumulation, and relieve vomiting symptoms.

4. Hyperemesis Gravidarum

(1) Hyperemesis gravidarum is a pathological condition of severe vomiting in early pregnancy, which can lead to water and electrolyte disorders and malnutrition.

(2) Glutathione can relieve nausea and vomiting symptoms, improve the quality of life of pregnant women, and help maintain normal nutrient intake.

5. Preeclampsia

(1) Preeclampsia, including late pregnancy toxemia, is a serious complication of pregnant and parturient women.

(2) As an adjuvant therapeutic drug, glutathione can help improve vascular endothelial function, reduce oxidative stress injury, and play a positive role in controlling blood pressure and delaying disease progression.

II. Contraindications of Glutathione Tablets

1. Contraindication for Allergic History

(1) It is contraindicated for patients who are allergic to the active ingredients of glutathione or any excipients.

(2) Patients with a history of drug allergy should inform their doctor before taking the drug.

2. Severe Hepatic and Renal Insufficiency

(1) Although glutathione itself is used for liver protection and detoxification, the use of it in patients with severe liver insufficiency requires careful evaluation.

(2) Drug metabolism and excretion depend on the liver and kidney, and severe dysfunction may affect efficacy and safety.

(3) It should be used under the guidance of a doctor after weighing the advantages and disadvantages.

3. Use with Caution for Hypersensitive Constitution

(1) A very small number of patients may experience allergic reactions, such as skin rashes.

(2) If an allergy occurs, the drug should be stopped immediately and medical attention should be sought.

(3) Patients with a history of sensitivity to sulfhydryl-containing compounds need to pay special attention and be closely observed during medication.

4. Instructions on Contraindicated Foods

Glutathione Tablets themselves have no specific contraindicated foods. However, considering that their main indications are poisoning and metabolic disorders, it is recommended during treatment:

(1) Avoid alcohol, which increases the liver burden and may offset the liver-protective effect of the drug.

(2) Avoid high-fat and fried foods to reduce the burden on the digestive system.

(3) Avoid contact with toxic chemical substances and food contaminated with heavy metals.

(4) Patients with hyperemesis gravidarum should eat small and frequent meals and choose light and easily digestible foods.

III. Medication for Special Populations of Glutathione Tablets

1. Medication for Pregnant Women

(1) Glutathione can be used for the treatment of hyperemesis gravidarum and preeclampsia.

(2) However, any medication during pregnancy should be carried out under the guidance of a doctor, taken strictly in accordance with the recommended dosage, and not increased or decreased without authorization.

(3) Medication in the first trimester of pregnancy needs to be more cautious, and it is necessary to evaluate whether the therapeutic benefit is greater than the potential risk.

2. Medication for Lactating Women

(1) The use of glutathione by lactating women should be cautious.

(2) It is unclear whether glutathione is secreted into breast milk. If breastfeeding is chosen during medication, close observation of the infant for abnormal reactions is required.

(3) If conditions permit, an appropriate interval can be set between medication and breastfeeding.

3. Medication for Children

(1) Glutathione can be used in children, especially for acetonemic vomiting (cyclic vomiting syndrome).

(2) When using the powder for children, the dosage should be accurately measured, and attention should be paid to moisture-proof storage.

(3) If side effects such as loss of appetite, nausea and vomiting occur, medical attention should be sought in a timely manner.

4. Medication for the Elderly

(1) The elderly can use glutathione at the conventional dosage, but attention should be paid to the impact of physiological decline in liver and kidney function on drug metabolism.

(2) The elderly often have multiple chronic diseases and take multiple drugs, so potential drug interactions need to be noted.

5. Patients with Hepatic and Renal Insufficiency

(1) Glutathione is used for detoxification and liver protection, and liver disease patients are one of its target populations.

(2) However, in patients with severe liver insufficiency, drug metabolism may change, and the dosage needs to be adjusted under the guidance of a doctor.

(3) Drug excretion may be slowed down in patients with renal insufficiency. Although glutathione has good safety, it is still recommended to start with a lower dosage and adjust according to the response.

6. Special Occupational Exposure Populations

(1) Occupational populations exposed to heavy metals, organophosphorus pesticides, sulfur dioxide gas, etc., can consider using glutathione as preventive or adjuvant therapy under the guidance of a doctor.

(2) Animal experiments have confirmed that it has an improving effect on sulfur dioxide gas poisoning and organophosphorus poisoning. However, preventive medication requires professional evaluation and should not be taken for a long time without authorization.