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Goserelin Acetate Implant (ZOLADEX®) is a sustained-release GnRH agonist used to suppress testosterone in prostate cancer. Administered subcutaneously every 12 weeks, it induces medical castration, slowing tumor progression.
Key indications include locally advanced (Stage B2-C) and metastatic prostate cancer, often combined with radiation or flutamide. Risks include tumor flare, cardiovascular events, and injection site injury. Monitoring testosterone levels and managing hyperglycemia are critical during therapy.
Locally Confined Prostate Cancer (Stage B2–C): Used in combination with flutamide and radiotherapy. Initiated 8 weeks prior to radiation and continued during therapy.
Advanced Prostate Cancer: Palliative treatment for metastatic diseas.
1. Dose: 10.8 mg administered subcutaneously every 12 weeks.
2. Site: Anterior abdominal wall below the navel line.
3. Technique:
3.1 Aseptic technique; avoid muscle/peritoneum penetration.
3.2 Insert needle at 30–45° angle; no aspiration required.
3.3 Monitor for vascular injury (risk in low BMI or anticoagulated patients).
4. Missed Dose: Adhere to 12-week schedule; brief delays permissible.
