Correct use of acotiamide is key to ensuring efficacy and safety.

I. Dosage and Administration

1. Standard Dosage

(1) The standard adult dosage is 100 mg once, three times a day, taken orally before meals.

(2) Each tablet contains acotiamide hydrochloride hydrate 100 mg, i.e., one tablet per dose.

2. Timing of Administration

(1) Acotiamide should be taken before meals.

(2) Strictly taking it before meals provides the best efficacy.

3. Treatment Duration

(1) Continuous medication for 4 weeks is recommended for efficacy evaluation.

(2) If symptoms do not improve significantly after one month of treatment, discontinuation should be considered.

(3) After symptom improvement, discontinuation should also be considered to avoid long-term unnecessary use.

II. Precautions for Use

1. Necessary Examinations Before Use

(1) Before using this drug, it is necessary to confirm the exclusion of organic diseases such as gastric cancer through examinations like upper gastrointestinal endoscopy.

(2) If symptoms persist and do not improve after medication, the possibility of organic diseases should still be considered, and further examination should be performed promptly.

2. Indications for Discontinuation

(1) Discontinuation due to inefficacy: If symptoms do not improve after one month of medication, discontinuation should be considered.

(2) Discontinuation due to efficacy: After sustained symptom improvement, active consideration should be given to discontinuation, and long-term maintenance is not recommended. In clinical trials, 75% of patients discontinued due to symptom improvement, and the improvement effect persisted for 12 weeks in half of those patients.

3. Special Population Precautions

(1) Pregnant women: Use only if the therapeutic benefit outweighs the risk.

(2) Lactating women: Animal studies (rats) show that the drug can be excreted into milk; the benefits and risks should be weighed before deciding on breastfeeding.

(3) Children: No clinical trials have been conducted; use is not recommended.

(4) Elderly: Physiological functions are generally declining; if any abnormalities occur, discontinue the drug promptly.

4. Special Note: Safe Use of PTP Packaging

(1) Be sure to remove the tablet from the PTP sheet before taking it; do not swallow the sheet whole.

(2) Accidental swallowing of the PTP sheet may cause sharp edges to pierce the esophageal mucosa, possibly leading to serious complications such as perforation and mediastinitis.

5. Drug Interaction Reminder

(1) Concomitant use with anticholinergic drugs (e.g., atropine) may reduce the efficacy of this drug.

(2) Concomitant use with cholinergic drugs (e.g., acetylcholine, neostigmine) may enhance the effects of both drugs and should be done with caution.

III. Healthy Lifestyle for Patients

In addition to drug therapy, lifestyle modifications are also important for relieving symptoms of functional dyspepsia. The following suggestions are for reference.

1. Reasonable Eating Habits

(1) Eat small, frequent meals: Avoid overeating at each meal to reduce postprandial fullness and early satiety.

(2) Chew thoroughly: Adequate chewing aids digestion and reduces gastric burden.

(3) Avoid irritating foods: Such as overly greasy, spicy, excessively hot or cold foods, which may induce or worsen symptoms.

(4) Keep a food diary: Identify and avoid personally intolerant foods.

2. Regular Daily Routine

(1) Set fixed meal times: Establish regular eating habits, avoiding irregular meal patterns.

(2) Ensure adequate sleep: Lack of sleep may worsen dyspepsia symptoms.

(3) Moderate activity after meals: Taking a walk after meals can promote gastric emptying, but avoid vigorous exercise.